IMP Dehydrogenase Inhibitors as Immunomodulators
نویسندگان
چکیده
منابع مشابه
IMP dehydrogenase from Pneumocystis carinii as a potential drug target.
Mycophenolic acid, a specific inhibitor of IMP dehydrogenase (IMPDH; EC 1.1.1.205), is a potent inhibitor of Pneumocystis carinii growth in culture, suggesting that IMPDH may be a sensitive target for chemotherapy in this organism. The IMPDH gene was cloned as a first step to characterizing the enzyme and developing selective inhibitors. A 1.3-kb fragment containing a portion of the P. carinii ...
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GTP cyclohydrolase I exhibits a positive homotropic cooperative binding to GTP, which raises the possibility of a role for GTP in regulating the nzyme reaction (Hatakeyama, K., Harada, T., Suzuki, S., Watanabe, Y., and Kagamiyama, H. (1989) J. Biol. Chem. 264, 21660-21664). We examined whether or not the intracellular GTP level is within the range of affecting GTP cyclohydrolase I activity, usi...
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Cryptosporidium parasites are a major cause of diarrhea and malnutrition in the developing world, a frequent cause of waterborne disease in the developed world, and a potential bioterrorism agent. Currently, available treatment is limited, and Cryptosporidium drug discovery remains largely unsuccessful. As a result, the pharmacokinetic properties required for in vivo efficacy have not been esta...
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IMP dehydrogenase (EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, is a promising target in antileukemic chemotherapy. We have isolated two distinct cDNA clones (types I and II) encoding IMP dehydrogenase from a human spleen cDNA library. Both clones encode closely related proteins of 514 residues showing 84% sequence identity. Northern hybridization analyses of poly(A)+ RN...
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The shikimic acid biosynthetic pathway, which operates in micro-organisms and higher plants but not in mammals, leads to several essential amino acids and also to a variety of other metabolites. It was hoped, therefore, that blockage of the pathway might have a damaging effect on plant metabolism, giving a useful commercial herbicide with selective toxicity. Shikimate dehydrogenase, the enzyme ...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 1993
ISSN: 0077-8923,1749-6632
DOI: 10.1111/j.1749-6632.1993.tb35869.x